Misfolded diabetes-mellitus peptide seeds amyloid-β aggregation
نویسندگان
چکیده
منابع مشابه
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
One of the neuropathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque, primarily composed of aggregated amyloid-beta (Abeta) peptide. In vitro, Abeta(1-42), the major alloform of Abeta found in plaques, self-assembles into fibrils at micromolar concentrations and acidic pH. Such conditions do not exist in the extracellular fluid of the brain where the pH is neutral and Abeta ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2017
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2017.5